What would be the most innovative front end environment to go with python for developing neuromorphism?

So essentially neuromorphism would be UI that adapts in real time to the needs of a neurodivergent, autistic user and anyone with a neurological condition triggers by visual or audio based triggers.

I want to go with something that is relatively new but obviously has a lot of documentation with. The product is very experimental and legally constrained research so this project is refraining from open source architecture as much as it possibly can

Please be kind.